The symposium will be a single track meeting consisting of a keynote lecture, 14 invited speakers, a small number of selected talks and 3 poster sessions. There will also be organised social events, culminating in a banquet and party on the final night.




Monday, 9th – 17h30, 19h30

1 Catarina Almeida Diversity in antigen recognition by Unconventional T cells
4 Bruno Bernardes de Jesus Silencing the long non-coding RNA antisense to Zeb2 facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency.
7 sergio Caja Galan Exosome Signalling: A road map to understand metastasis
10 Ana Filipa Cardoso Regulation of type 2 innate lymphoid cells at barrier sites
13 Zita Carvalho-Santos Sugar appetite is controlled by the metabolic program of germline cells
16 Sofia Cerqueira Eradicating HIV-1 follicular sanctuaries through immunotherapy
19 Dina Coelho Culling less fit neurons protects against amyloid-β-induced brain damage and cognitive and motor decline
22 Irina Dominova Postnatal development of glial GLAST-positive cells
25 Euclides Fernandes Póvoa Unraveling the regulatory network of a complete C. elegans neural cell lineage
28 Ines Ferreira Exosomes as intermediary of Gut-Liver communication in type 2 diabetes
31 Patricia Francisco Commensal bacteria and essential amino acids control food choice behavior and reproduction
34 Cristina Godinho-Silva Control of innate lymphoid cells and enteric defence by circadian inputs
37 André Macedo VEnCodes allow genetic access to normal and cancer cells in the human body
40 Yoon-Gu Jang Spatial activation of TORC1 is regulated by Hedgehog and E2F1 signaling in Drosophila eye.
43 Seongsoo Lee Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer’s disease treatment
46 Carlos Lopez Fernandez de Castillejo Defining the role of endothelial notch activity in the biology of adult hematopoietic stem and progenitor cells
49 Joana Maia Bone marrow cells recruitment: players at pre-metastatic niche and metastatic progression
52 Sofia Mensurado ROS-expressing neutrophils inhibit pro-tumor IL-17-producing gamma-delta T cells
55 Shyama Nandakumar Cell cycle reentry in the optic lobes of the adult Drosophila melanogaster brain
58 Vaibhav Pai Understanding the biophysical basis of teratogenesis and its cure: a computational model of developmental bioelectrics for repair of neuroteratorgenesis in vivo
61 Silas Pinto Enaxocin extends lifespan of C. elegans by inhibiting MIR-35-5P and mimicking dietary restriction
64 Om Rathore Spliceosome subunit Salsa is required for efficient splicing of gurkentranscript during Drosophila oogensis.
67 Nadia Rivero Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca2+]i overload and NF-κB activation
70 Elena Santana Martín Molecular chaperones in synaptogenesis and stress
73 Nadia Silva Maternal thyroid hormones deficit during zebrafish embryogenesis hinders development of specific cell populations in the spinal cord
76 Ana Raquel Tomás The Molecular and Transgenic Tools platform at the Champalimaud Foundation
79 Hafize Uzun Defibrotide attenuates oxidative damage of the heart, liver, brain, and kidney tissues in a rat model of chronic obstructive pulmonary disease
83 Rita Esteves Development of optogenetic tools for manipulating neuronal activity and behaviour in zebrafish


Tuesday, 10th – 13h30, 15h30

2 Raquel Andrade The Segmentation Clock in Temporal Control of HoxB Gene Expression
5 Joanna Bou Saab The Role of E78 in Metabolism
8 Henrique Camara The systemic RNAi pathway controls longevity, development and fertility in C. elegans
11 Vânia Cardoso Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
14 Sergio Casas Tinto Glioblastoma network deplete neuronal wg and induces neurodegeneration
17 Ana Catarina Certal A new, easy and reliable cryopreservation protocol for zebrafish sperm
20 Adam Dobson Beneficial and deleterious long-term programming of ageing and transcription by early-life interventions.
23 Francisco Esteves Neural circuits controlling Prolactin release during sexual behavior
26 Mafalda Ferreira Functional characterisation of tumour-derived exosomes in the zebrafish xenograft model
29 Fábio Fiúza Rosa Programming antigen-presenting dendritic cells from fibroblasts
32 Irene García-González Studying endothelial development in zebrafish using functional mosaics.
35 Ana Gonçalves Robo/Slit signaling during normal and hypoplastic lung development in CDH context: expression and functional studies
38 Raffaella Gozzelino Inflammation-driven disruption of iron homeostasis in Parkinson’s disease
41 Malgorzata Lasota Prognostic and therapeutic significance of the c-KIT receptor expression and mutation in acute myeloid leukemia
44 Constanze Lenschow Development of rat female genital cortex and control of female puberty by sexual touch
47 Raissa Ludwig Serum of Dietary Restricted Mice Down-Regulates Ucp1 in Murine Differentiated Brown Adipocytes
50 Zvonimir Marelja Lysosomal cystine efflux through CTNS inactivates mTOR upon fasting in Drosophila.
53 Mihailo Mirkovic Drosophila melanogaster brain is the limiting tissue in response to developmental aneuploidy
56 Joana F Neves Intestinal organoids co-cultures as a novel system to study intestinal lymphocytes
59 Pedro H Papotto Inflammatory IL-23 signals induce de novo differentiation of peripheral γδ 17 T cells from adult bone marrow-derived precursors
62 Sofia Rebelo A new tool to study macrophage polarization and plasticity within the tumor microenvironment
65 Mariana Reis The role of cell competition in Drosophila’s model of Alzheimer’s Disease
68 Patrícia Rodrigues The right centrosome number: How to eliminate centrosomes
71 Ines Sequeira Immunomodulatory role of Keratin 76 in oral and gastric cancer
74 Pedro Sousa-Victor MANF is a systemic regulator of metabolic and immune homeostasis during aging
77 Marlene Trindade Is there a role for maternal thyroid hormones on pericyte recruitment during zebrafish blood-hindbrain barrier development?
80 Samuel Walker The gustatory basis of protein-specific appetite in Drosophila
82 Helena Brigas Physiological roles of T cell subsets in the male reproductive tract


Wednesday, 11th – 13h30, 15h30

3 Mayank Bansal A Functional Genomics approach to dissect the pathways involved in the Mesodermal Specification of Endothelial and Blood Progenitor cells and its Lineage by using CRISPR Cas9
6 Baylor Brangers Disecting the Anatomy of the Periaqueductal Gray
9 Magda Cannata Serio Mutations in ATP6AP2 are associated to congenital disorders of glycosylation with autophagic defects
12 Marta Carus-Cadavieco Gamma oscillations organize top-down signaling to hypothalamus and enable food seeking
15 Diogo Castro MyT1 counteracts the neural progenitor program to promote vertebrate neurogenesis
18 Andrea Chai Spatiotemporally reproducible genetic perturbation for efficient large-scale studies of non-autonomous effects.
21 Rita Domingues Control of innate lymphoid cells and enteric defence by circadian inputs
24 Marta Estrada Modelling tumor-stroma interactions to address disease progression and drug response mechanisms
27 Manuela Ferreira Control of natural intraepithelial lymphocytes and early life intestinal defence by diet-derived retinoids
30 Irina Fonseca Consequences of centriole aberrations in cancer
33 Alexandre Gaspar Maia Modulation of enhancer activity in cancer and cellular reprogramming by the histone variant macroH2A
36 Ana Gonçalves Revealing the epithelial cells dynamics associated with the normal and hypoplastic fetal lung development
39 Anna Jagusiak Carbon nanotubes dispersed with supramolecular compounds as a potential drug delivery system – properties of the complex and mechanism of the interaction
42 Katerina Lawlor Understanding the role of competitive interactions between cells in glioblastoma
45 Carla A.M. Lopes Timing and regulation of centrosome amplification in human tumorigenesis
48 Wen Luo The role of Notch in coronary vessel formation and remodeling
51 Ana Rita Mendes Unravelling the circuits involved in ejaculation in mice
54 Kenta Morimoto Mechanical stress-induced cell-cycle modification in organ proportioning
57 Sandrina Nóbrega Pereira VEGFR-2 signaling regulates the sensitivity of acute myeloid leukemia to chemotherapy by reprogramming mitochondrial metabolism
60 Cristina Pina Kat2a regulates AML self-renewal and controls transcriptional heterogeneity in malignant and developmental stem cell systems
63 Inês Preguiça The ventromedial hypothalamus in female mice sexual receptivity
66 Julie Ribot Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and cognitive behaviour.
69 Pedro Rosmaninho Zeb1 potentiates genome-wide gene transcription in glioblastoma cancer stem cells via a novel Lef1-dependent mechanism
72 Karine Serre A myeloid cell-centric view of cancer: anti-tumour macrophages – myth or reality?
75 Ana Teresa Tavares Identification of novel hemangioblast genes expressed in the early embryo
78 Gülay Üzüm Effect of erythropoietin pretreatment on oxidative stress caused by pentylenetetrazole-induced seizures in kidney, liver and heart
81 Silvia Schwartz Molecular mechanisms of neural stem cell activation following brain injury in Drosophila melanogaster